Enabling Forensic
Immunology
The immune system is not just an army; it’s also an archive. Imprint aims to decode that archive at scale.
We may not know what causes disease, but the immune system does. IMPRINT is developing AI tools to read and analyze immune memory signatures, providing a new approach to identify hidden causes of chronic disease.
Effective treatment starts
with understanding
Many chronic conditions, including autoimmune diseases, long-COVID, psychiatric disorders, and dementia, remain incurable because we don’t know what causes them. Scientists may not know what causes many chronic diseases—but our immune system does.
The immune system stores a detailed record of everything it encounters over our lifetime (infections, allergies, cancers, autoimmunity), including hidden causes of disease. Currently, we can neither read nor decipher this massive, distributed archive. If we could access and translate the immunological record, we could identify unknown causes of chronic disease, unlocking new treatments and cures.
Unlocking immune histories
to advance disease treatment
IMPRINT is building machine learning immunology tools and fit-for-purpose datasets to reconstruct immune histories from memory B cells and T cells to uncover the causes of chronic disease. Unlocking and decoding this data will identify new disease mechanisms and therapeutic targets, enabling the development of diagnostics, cures, and treatments.
IMPRINT’s mission is to create forensic immunology research tools that unlock the power of the immune repertoire to understand and cure disease.
Founded in 2023, IMPRINT emerged from stealth on the TED Mainstage earlier this year.
Watch our announcement here
For a technical review, check out our latest paper:
Reading the repertoire: Progress in adaptive immune receptor analysis using machine learning (Cell Systems, 2024)
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Beck Brachman, PhD
Cofounder & CEO
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Victor Greiff, PhD
Cofounder & CTO
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Corinna Calhoun
COO
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William Hepworth
CFO
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Alvin Meda
Senior Operations Manager
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Meimei Shan, MD, PhD
Senior Sequencing Scientist
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Julien Limenitakis, PhD
Senior Computational Immunologist
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Armen Enikolopov, PhD
Senior Molecular Biology Scientist
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Philipp Fleig, PhD
Senior ML Scientist
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Giulio Isacchini, PhD
ML Scientist
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Sami Kebede
Sequencing Scientist
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Isaac Daviet, MS
Research Associate
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Jiaxing Liu
Senior Research Assistant
Imprint is a Focused Research Organization.
Focused Research Organizations (FROs) are built to make the impossible possible. These time-bound initiatives deliver deep-tech public goods that accelerate entire fields of science and technology. Like DARPA programs, FROs take on audacious, engineering-heavy projects, but move with the speed, focus, and drive of the best deep-tech startups. Small, mission-obsessed teams. High stakes. Breakthrough impact.
Imprint is supported by Eric and Wendy Schmidt, Convergent Research, the New York City Economic Development Corporation, and Peter Reinhardt.